Order Aldactone (spironolactone) online in the USA with fast delivery

Product Name	Aldactone
Dosage	25 mg, 50 mg, 100 mg
Active Ingredient	Spironolactone
Form	Oral Tablets
Description	Prescription potassium-sparing diuretic used in the USA for heart failure, resistant hypertension, edema (cirrhosis/nephrotic syndrome), and primary hyperaldosteronism; also used off‑label for acne, hirsutism, and PCOS in appropriate patients.
How to order in the USA	Through our partner online pharmacy with a quick US‑licensed telehealth evaluation and prescription when appropriate

Aldactone (spironolactone) is a well-established prescription medicine in the United States. It belongs to the class of mineralocorticoid receptor antagonists (MRAs), often called potassium-sparing diuretics. In US practice, spironolactone is widely used to help manage heart failure with reduced ejection fraction, resistant hypertension, edema associated with cirrhosis or nephrotic syndrome, and primary hyperaldosteronism. It is also prescribed off-label for select dermatologic and endocrine conditions such as adult female acne, hirsutism, and PCOS when appropriate. Aldactone tablets are commonly available in 25 mg, 50 mg, and 100 mg strengths.

The brand-name product Aldactone is approved by the US Food and Drug Administration (FDA). Multiple FDA-approved generics of spironolactone are also available nationwide, which can significantly reduce out-of-pocket costs. Because spironolactone is prescription-only in the USA, a licensed clinician must evaluate whether it is right and safe for you. Our partner pharmacy offers convenient online care: complete a short questionnaire, consult with a US-licensed provider, and—if clinically appropriate—receive a prescription and fast home delivery from a licensed pharmacy.

Aldactone cost in the USA

Both brand-name Aldactone and generic spironolactone are available throughout the USA. Generic versions are typically the most budget-friendly choice and contain the exact same active ingredient and dosage strengths as the brand.

Typical price ranges (may vary by location, insurance, and pharmacy):

• Spironolactone 25 mg: often under $15–$25 for 30 tablets with common pharmacy discounts
• Spironolactone 50 mg: roughly $15–$35 for 30 tablets with discounts
• Spironolactone 100 mg: roughly $20–$45 for 30 tablets with discounts

Brand-name Aldactone can cost more, depending on your plan and pharmacy. Many patients save by choosing generics or 90-day fills for chronic conditions. Our partner platform surfaces competitive pricing and shows your options during checkout. Final pricing depends on dosage, quantity, pharmacy network, and whether you use insurance or pay cash with available coupons.

Pro tip: If you are starting therapy for heart failure or resistant hypertension, ask your clinician whether a 90-day generic supply makes sense. It often reduces the per-tablet cost and minimizes refill trips.

Where can I buy Aldactone in the USA?

If your clinician has recommended spironolactone or you are seeking a medical review to determine whether Aldactone is appropriate, you can complete a secure online visit through our partner platform. A US-licensed provider will review your medical history—including kidney function, current medications, and potassium levels—then decide whether to prescribe spironolactone. If prescribed, your medication is shipped discreetly to your door from a licensed US pharmacy.

We collaborate with established pharmacy partners that prioritize patient safety, transparent pricing, and prompt delivery across the United States. Whether you’re managing a chronic condition like heart failure or resistant hypertension, or exploring off-label use for acne under clinician guidance, you can rely on convenient care and responsive support.

The online experience is particularly helpful for those who find in-person visits difficult or prefer the privacy and convenience of telehealth. Pharmacists and clinicians remain available to answer questions about dosing, side effects, and potential interactions. Your safety comes first, and prescriptions are only issued when clinically appropriate.

Aldactone in the USA

Getting started is straightforward: complete the intake form, upload any recent labs if available (especially potassium and kidney function), and list all medications and supplements you are currently taking. A US-licensed provider will assess your case and, if suitable, send the prescription to a partner pharmacy for immediate processing and shipment.

What is Aldactone (spironolactone)?

Spironolactone is a steroidal mineralocorticoid receptor antagonist. It blocks the effects of aldosterone, a hormone that promotes sodium and water retention and potassium excretion. By limiting aldosterone’s action in the kidneys, spironolactone increases sodium and water excretion while conserving potassium. This helps reduce fluid overload and lower blood pressure. Beyond its diuretic effects, spironolactone exerts anti-androgen receptor activity, which underlies some off-label dermatologic uses in women.

Clinically, spironolactone is part of guideline-directed medical therapy for heart failure with reduced ejection fraction (HFrEF) in appropriate patients. It is also commonly used to treat resistant hypertension, edema in cirrhosis (ascites) or nephrotic syndrome, and both diagnostic and treatment phases of primary hyperaldosteronism. Off-label, clinicians may prescribe it for adult female acne, hirsutism, and PCOS-related hyperandrogenism after weighing benefits and risks.

Because spironolactone can raise serum potassium, it must be used with careful monitoring in people with chronic kidney disease or those taking other medicines that increase potassium.

Aldactone for heart failure (HFrEF)

In heart failure with reduced ejection fraction, overactivation of neurohormonal pathways (including the renin-angiotensin-aldosterone system) contributes to fluid retention, remodeling, and disease progression. Adding an MRA such as spironolactone to foundational therapy can reduce hospitalizations and improve survival in appropriately selected patients. Typical candidates have an eGFR above 30 mL/min/1.73 m² and potassium below or equal to 5.0 mEq/L at baseline.

Spironolactone is often started at 12.5–25 mg once daily and titrated based on potassium and renal function. Your clinician may check labs within 3–7 days after initiation and again at 1 month, then periodically (for example, every 3 months) once stable. Dose adjustments depend on blood potassium levels, kidney function, and clinical response. Never adjust your dose without medical guidance.

Common concomitant therapies in HFrEF include an ACE inhibitor/ARB/ARNI, a beta-blocker, and in many cases an SGLT2 inhibitor and a loop diuretic. Your clinician will individualize your regimen.

The importance of mineralocorticoid receptor blockade

Blocking aldosterone’s effects helps reduce sodium retention, limit fibrosis and scarring in the heart, and mitigate harmful remodeling. This mechanism complements ACE inhibitors/ARBs/ARNIs and beta-blockers. In properly selected patients, MRAs are considered a key pillar of heart failure management.

Aldactone for resistant hypertension

Resistant hypertension—blood pressure that remains above goal despite appropriate lifestyle measures and the use of at least three antihypertensive agents (including a diuretic)—is commonly driven by aldosterone excess or sodium retention. Spironolactone is frequently effective as an add-on therapy in resistant hypertension. Typical doses range from 12.5–50 mg daily depending on blood pressure response and tolerability.

Your clinician will consider underlying causes (such as primary hyperaldosteronism) and evaluate your medication list and kidney function. Regular monitoring of potassium and creatinine is essential, especially after initiating or adjusting the dose.

Does Aldactone have anti-androgen properties?

Yes. Spironolactone has anti-androgenic activity. In dermatology and endocrinology, this property is used off-label to help manage acne, hirsutism, and other hyperandrogenic symptoms in appropriate female patients. It is generally combined with effective contraception in women of reproductive potential due to potential risks to a male fetus. Spironolactone is not typically used for acne in men because of the risk of gynecomastia and sexual side effects.

Aldactone for acne and hormonal skin concerns (off-label)

In adult women with persistent hormonal acne, spironolactone can decrease sebum production and reduce inflammatory lesions. Dermatologists often start at 50 mg daily and adjust within a 50–200 mg/day range based on response and tolerability. Clinical improvement is commonly observed after 6–12 weeks, with continued gains over several months. Because the medicine is anti-androgenic, effective contraception is advised in women who could become pregnant.

In hirsutism related to PCOS or idiopathic hyperandrogenism, clinicians may use spironolactone as part of a broader plan that can include lifestyle measures, combined hormonal contraception, and other therapies. Electrolyte and kidney function monitoring remains important.

Aldactone and hair/skin: what to know

Some clinicians prescribe spironolactone off-label for female pattern hair loss (androgenetic alopecia) as part of a multifaceted treatment plan. Evidence suggests benefit in select patients, especially when combined with other therapies recommended by a dermatologist. It is not a rapid solution: results, if they occur, build gradually over months.

For skin health, patients often ask about dryness, oiliness, or changes in menstrual cycles. While many tolerate spironolactone well, menstrual irregularities and breast tenderness can occur at higher doses. Always discuss persistent or concerning effects with your clinician; dose adjustments or alternative strategies may be considered.

Mechanism of action: how spironolactone works

Spironolactone antagonizes aldosterone at the mineralocorticoid receptor in the distal nephron, decreasing sodium reabsorption and reducing potassium excretion. The result is natriuresis (salt loss) with relative potassium conservation. Its anti-androgen activity occurs through competitive inhibition at androgen receptors and effects on androgen synthesis. These mechanisms explain both its cardiovascular and dermatologic use cases.

Safety and important warnings

The most significant risk with spironolactone is hyperkalemia (high potassium), which can be dangerous. Risk factors include chronic kidney disease, older age, diabetes, dehydration, and concomitant use of other drugs that raise potassium (e.g., ACE inhibitors, ARBs, aliskiren, potassium supplements, salt substitutes containing potassium, TMP-SMX, cyclosporine, tacrolimus, and heparins). Spironolactone is contraindicated in anuria, acute renal insufficiency, and hyperkalemia. It should not be used in Addison’s disease or with other potassium-sparing diuretics unless specifically directed by a specialist.

Baseline and follow-up labs (potassium and creatinine/eGFR) are essential after starting or adjusting the dose. Contact your clinician immediately if you develop muscle weakness, palpitations, significant fatigue, or other symptoms suggestive of high potassium.

Aldactone dosage for adults

Dosing is individualized and based on indication, kidney function, potassium levels, and concomitant medications. Typical adult dosing examples include:

• Heart failure (HFrEF): 12.5–25 mg once daily, titrated to 25–50 mg daily as tolerated and as potassium/renal function allow
• Resistant hypertension: 12.5–50 mg daily, adjusted to blood pressure response
• Edema (cirrhosis/nephrotic syndrome): 25–200 mg daily in divided doses, individualized to edema control and labs
• Primary hyperaldosteronism (diagnostic/short-term pre-op or chronic treatment when surgery not possible): 100–400 mg/day in divided doses, adjusted by response and labs
• Dermatologic/off-label (adult female acne, hirsutism): commonly 50–200 mg/day, individualized

Never change your dose on your own. Your clinician will determine a safe starting dose and follow-up schedule for lab monitoring, especially during the first few weeks.

Aldactone dosing and titration guidance

General principles your clinician may follow include:

• Check baseline potassium and kidney function (creatinine/eGFR)
• Start low (e.g., 12.5–25 mg daily) and titrate based on clinical response and labs
• Recheck potassium/creatinine within 3–7 days of initiation or dose increase, then at 2–4 weeks, and periodically once stable
• Use caution with concomitant ACEi/ARB/ARNI; monitor closely
• Advise patients to avoid salt substitutes containing potassium unless a clinician has approved them

Edema and ascites in cirrhosis

In cirrhosis with ascites, aldosterone levels are often elevated, leading to fluid accumulation. Spironolactone is a mainstay therapy and is frequently combined with a loop diuretic such as furosemide. A common starting approach is spironolactone 100 mg with furosemide 40 mg daily, titrated carefully to achieve a slow, steady reduction in fluid while preserving kidney function and electrolyte balance. Your clinician will tailor the plan, monitor weight, abdominal girth, electrolytes, and kidney function, and adjust doses accordingly.

Primary hyperaldosteronism

Primary hyperaldosteronism (Conn’s syndrome) results in excessive aldosterone production, leading to hypertension and often low potassium. Spironolactone can be used in the diagnostic phase and as long-term therapy (if surgery is not an option or as a bridge to surgery). Dosing may range from 100–400 mg/day in divided doses, adjusted based on blood pressure, potassium, kidney function, and symptom control. Alternatives such as eplerenone may be chosen in patients who develop endocrine side effects on spironolactone.

How to take Aldactone

Take spironolactone exactly as prescribed. It may be taken with or without food, but be consistent to reduce variability in absorption. Swallow tablets with water. If you miss a dose, take it when you remember unless it is close to your next scheduled dose. Do not double up doses.

Because spironolactone can increase potassium levels, your clinician may ask you to limit high-potassium salt substitutes and monitor dietary potassium. Follow lab check schedules and report symptoms such as palpitations, significant fatigue, muscle weakness, or lightheadedness.

Pregnancy and breastfeeding

Spironolactone is generally not recommended during pregnancy due to its anti-androgenic properties and potential risk to a male fetus. Women of reproductive potential should use effective contraception while taking spironolactone and discuss family planning with their clinician. During breastfeeding, small amounts of spironolactone and its metabolites may be present in milk; discuss risks and benefits with your healthcare provider to determine the best approach for you and your infant.

Pharmacist’s tips for taking Aldactone

Follow your lab schedule. Early and consistent monitoring of potassium and kidney function helps prevent complications.

Know the signs of hyperkalemia: unusual muscle weakness, heart palpitations, significant fatigue, or feeling faint. Contact your clinician promptly if these occur.

Review all medications and supplements with your care team, particularly ACE inhibitors, ARBs, aliskiren, NSAIDs, TMP-SMX, cyclosporine, tacrolimus, heparin, potassium supplements, and salt substitutes. These may raise potassium or interact with spironolactone.

If you are taking digoxin or lithium, ask about additional monitoring. Spironolactone can affect digoxin levels and diuretics can increase lithium toxicity risk.

Safety Precautions

Do not use spironolactone if you have hyperkalemia, anuria, or acute renal insufficiency. Use caution in chronic kidney disease and in older adults who are at greater risk for electrolyte disturbances.

Avoid high-potassium salt substitutes unless approved by your clinician. Keep hydrated, especially during illness or heat exposure; dehydration can worsen kidney function and elevate potassium.

Report endocrine side effects such as breast tenderness, gynecomastia, or menstrual irregularities. Dose adjustments or alternative medicines may be considered.

Aldactone side effects

Common effects may include dizziness, increased urination, gastrointestinal upset (nausea or diarrhea), or mild fatigue. Endocrine-related effects can include gynecomastia in males and menstrual irregularities or breast tenderness in females. Serious adverse effects can include hyperkalemia and, rarely, severe skin reactions or significant kidney impairment. Seek medical attention immediately if you experience symptoms of severely high potassium, such as muscle paralysis, chest pain, or fainting.

Side effect likelihood varies by dose, indication, kidney function, and concomitant medications. Your clinician can help mitigate risks with careful dosing and monitoring.

Side effects by condition and what to watch for

In patients using spironolactone for hypertension, possible effects include:

• dizziness or lightheadedness, especially when standing
• fatigue or headache
• gastrointestinal upset (nausea, diarrhea)
• elevated potassium (muscle weakness, palpitations)
• mild hyponatremia (rare)

For patients with heart failure on multidrug regimens, symptoms may include:

• increased urination
• low blood pressure with standing (orthostatic hypotension)
• electrolyte changes (especially hyperkalemia)
• kidney function changes that require dose adjustments
• rare endocrine effects (gynecomastia in males, breast tenderness)

In adults using spironolactone off-label for acne or hirsutism, the following may occur:

• menstrual irregularities (spotting, changes in cycle length)
• breast tenderness or fullness
• mild dizziness or fatigue
• headache
• elevated potassium risk if combined with interacting medications

Reporting side effects

If you notice any side effects, contact your clinician or pharmacist. If you experience symptoms suggestive of dangerously high potassium (such as severe muscle weakness, chest pain, or fainting), seek urgent care. You can also report adverse events to the FDA MedWatch program.

Interaction of Aldactone with other medicines

Spironolactone can interact with certain prescription and over-the-counter medicines, vitamins, and supplements. Always provide your complete medication list to your clinician and pharmacist. Important interactions include:

• ACE inhibitors (e.g., lisinopril), ARBs (e.g., losartan), ARNI (sacubitril/valsartan), and aliskiren: increased risk of hyperkalemia; monitor closely
• Potassium supplements and salt substitutes containing potassium: avoid unless specifically directed
• Other potassium-sparing diuretics (eplerenone, amiloride, triamterene): avoid combination unless specialist-directed
• NSAIDs (ibuprofen, naproxen, celecoxib): may reduce kidney function and blunt diuretic effect; monitor
• Trimethoprim-sulfamethoxazole (TMP-SMX): markedly increases risk of hyperkalemia; avoid or monitor very closely
• Cyclosporine or tacrolimus: can elevate potassium; monitor
• Heparin and low-molecular-weight heparins: can raise potassium; monitor
• Digoxin: spironolactone can affect digoxin levels; monitoring may be needed
• Lithium: diuretics can increase lithium toxicity; avoid or monitor carefully
• Drospirenone-containing contraceptives: additive potassium-sparing effect; consider monitoring

This list is not exhaustive. Your clinician will help manage potential interactions through dose adjustments, lab monitoring, or medication changes.

Recommendations from our specialists

If you have heart failure, resistant hypertension, edema from liver disease, or symptoms suggestive of primary hyperaldosteronism, timely evaluation is important. For dermatologic concerns such as adult female acne or hirsutism, ask your clinician whether spironolactone is appropriate and what monitoring is required. Keep an up-to-date list of all medications and supplements, stay on schedule with lab checks, and maintain regular follow-up. A small buffer supply (when prescribed) ensures you don’t miss doses while awaiting refills.

Ready to take control of your health? Order Aldactone today!

Get clinically guided care and reliable delivery from our trusted online pharmacy partners.

• US-licensed clinicians — quick telehealth review and prescription when appropriate
• Fast, discreet shipping across the United States
• Genuine medication from licensed US pharmacies
• Affordable options including FDA-approved generics in 25 mg, 50 mg, and 100 mg strengths
• Dedicated support from pharmacists and care teams

Join patients nationwide who trust us for convenience and care quality. Start your online visit, and if prescribed, receive Aldactone delivered to your door.

Buy Aldactone Now